RT Book, Section
A1 Tuddenham, Susan A.
A1 Zenilman, Jonathan M.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161341272
T1 Syphilis
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK accessmedicine.mhmedical.com/content.aspx?aid=1161341272
RD 2024/04/19
AB AT-A-GLANCEA  disease  caused  by  the  spirochete  Treponema  pallidum  subspecies  pallidum  that  is  almost  exclusively  sexually  transmitted.In  the  United  States,  syphilis  disproportionately  affects  men  who  have  sex  with  men  and  African  American  heterosexual  communities.The  most  common  and  recognizable  manifestations  are  usually  cutaneous.Syphilis  passes  through  4  distinct  clinical  phases:Primary  stage,  characterized  by  a  chancre.Secondary  stage,  characterized  typically  by  skin  eruption(s)  with  or  without  lymphadenopathy  and  organ  disease.A  latent  period  of  varied  duration,  characterized  by  the  absence  of  signs  or  symptoms  of  disease,  with  only  reactive  serologic  tests  as  evidence  of  infection.Tertiary  stage,  with  cutaneous,  neurologic,  or  cardiovascular  manifestations.Neurosyphilis  and  ophthalmic  syphilis  can  occur  at  any  stage.The  recommended  treatment  for  most  types  of  syphilis  is  benzathine  penicillin  G,  with  dose  and  administration  schedule  determined  by  disease  stage.Any  patient  diagnosed  with  syphilis  should  be  tested  for  other  sexually  transmitted  infections,  including  HIV.