RT Book, Section A1 Tang, Jean Y. A1 Epstein, Jr., Ervin H. A1 Oro, Anthony E. A2 Kang, Sewon A2 Amagai, Masayuki A2 Bruckner, Anna L. A2 Enk, Alexander H. A2 Margolis, David J. A2 McMichael, Amy J. A2 Orringer, Jeffrey S. SR Print(0) ID 1161335298 T1 Basal Cell Carcinoma and Basal Cell Nevus Syndrome T2 Fitzpatrick's Dermatology, 9e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071837798 LK accessmedicine.mhmedical.com/content.aspx?aid=1161335298 RD 2024/10/11 AB AT-A-GLANCEBasal cell carcinomas (BCCs) are the most common cancers in humans. All BCCs have mutations activating the Hedgehog signaling pathway.BCCs are caused by exposure to ultraviolet light and are associated with PTCH1 gene mutation in most cases.BCCs are locally destructive and rarely metastatic.BCCs are primarily treated by surgical excision, electrodesiccation and curettage, Mohs micrographic surgery, and topical agents.