RT Book, Section A1 Weenig, Roger H. A1 Pittelkow, Mark R. A2 Kang, Sewon A2 Amagai, Masayuki A2 Bruckner, Anna L. A2 Enk, Alexander H. A2 Margolis, David J. A2 McMichael, Amy J. A2 Orringer, Jeffrey S. SR Print(0) ID 1161333047 T1 Scleredema and Scleromyxedema T2 Fitzpatrick's Dermatology, 9e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071837798 LK accessmedicine.mhmedical.com/content.aspx?aid=1161333047 RD 2024/10/08 AB Skin disorders that are characterized by increased mucin content, excessive collagen deposition, or fibrocyte hyperplasia are designated as mucinoses, sclerosing disorders, or fibrosing disorders, respectively. As the fibrocyte (fibroblast) is the cellular component of their pathogenesis, these conditions are aptly viewed as various forms of “fibropathy.” In some conditions, one fibrocyte product predominates, such as excessive mucin production in pretibial myxedema or collagen deposition in scleroderma. In others conditions there is a combination of excessive mucin and collagen deposition (scleredema) or excessive mucin deposition and fibrocyte hyperplasia (scleromyxedema and nephrogenic systemic fibrosis). Hence, the nosology of some of these conditions does not accurately describe what is observed histopathologically. For example, “fibromyxedema” more accurately depicts the histopathogenesis of scleromyxedema, as scleromyxedema implies a combination of sclerosis and mucinosis, which more accurately describes scleredema.