RT Book, Section
A1 Ujiie, Hideyuki
A1 Shimizu, Hiroshi
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161329698
T1 Eosinophilic Diseases
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK accessmedicine.mhmedical.com/content.aspx?aid=1161329698
RD 2024/04/24
AB AT-A-GLANCEEosinophils  are  bone  marrow–derived  cells  that  circulate  transiently  and  normally  account  for  up  to  6%  (up  to  600/mm3)  of  circulating  blood  leukocytes.Eosinophils  primarily  are  tissue-dwelling  cells,  but  only  in  certain  tissues  in  humans,  with  an  average  tissue  life  span  of  2  to  5  days  that  may  be  increased  with  eosinophil  survival  factors  for  up  to  14  days.As  proinflammatory  cells,  the  presence  of  eosinophils  within  most  tissues  is  associated  with  pathologic  states  that  include  infections,  allergic  reactions  and  atopic  diseases,  fibrotic  disorders,  reactive  eosinophilias,  and  hypereosinophilic  syndromes.Eosinophils  play  a  role  in  innate  and  adaptive  immune  responses,  which  may  explain  why  they  are  present  in  normal,  noninflamed  tissues  such  as  the  gastrointestinal  tract  and  lymphoid  tissues.This  section  reviews  the  biologic  actions  of  eosinophils  with  particular  focus  on  what  controls  eosinophil  production,  activation,  and  tissue  trafficking.Pharmacologic  manipulation  of  eosinophil  inflammation  is  possible  as  new,  more  specific  strategies  are  emerging.