RT Book, Section A1 Vandergriff, Travis A2 Kang, Sewon A2 Amagai, Masayuki A2 Bruckner, Anna L. A2 Enk, Alexander H. A2 Margolis, David J. A2 McMichael, Amy J. A2 Orringer, Jeffrey S. SR Print(0) ID 1161327129 T1 Actinic Prurigo T2 Fitzpatrick's Dermatology, 9e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071837798 LK accessmedicine.mhmedical.com/content.aspx?aid=1161327129 RD 2024/09/19 AB AT-A-GLANCEA rare chronic pruritic and excoriated papular or nodular eruption of sun-exposed and, to a lesser extent, nonexposed skin.Beginning in childhood, it may remit at puberty, exacerbate most often in summer, and fade in winter.Indigenous peoples of North and South America are disproportionately affected.Association with HLA-DR4, specifically the HLA- DRB1*0407 and DRB1*0401 variantsPrevention through avoidance of sunlight is the first-line therapy; thalidomide or other immunosuppressive agents may be required.