RT Book, Section A1 Dyer, Jonathan A. A2 Kang, Sewon A2 Amagai, Masayuki A2 Bruckner, Anna L. A2 Enk, Alexander H. A2 Margolis, David J. A2 McMichael, Amy J. A2 Orringer, Jeffrey S. SR Print(0) ID 1161323641 T1 Genetic Disorders Affecting Dermal Connective Tissue T2 Fitzpatrick's Dermatology, 9e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071837798 LK accessmedicine.mhmedical.com/content.aspx?aid=1161323641 RD 2024/03/28 AB Inherited connective tissue disorders are clinically and genetically diverse conditions affecting the skin, joints, and a variety of extracutaneous tissues, including the cardiovascular (CV) system. The nature and severity of the skin phenotype is dependent on the type of mutation as well as the role of the affected protein on dermal structure and function (see Chaps. 15 and 18). The diagnosis of many inherited connective tissue disorders is clinical, although Clinical Laboratory Improvement Amendments (1988) (CLIA)-approved genetic testing is increasingly available. A listing of research laboratories that might offer testing can be found at http://www.genetests.org.