RT Book, Section
A1 Desman, Garrett T.
A1 Barnhill, Raymond L.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161323376
T1 Acquired Perforating Disorders
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK accessmedicine.mhmedical.com/content.aspx?aid=1161323376
RD 2024/04/18
AB AT-A-GLANCEAcquired  perforating  disorders  represent  a  group  of  separately  identified  cutaneous  disorders  that  occur  most  often  in  the  setting  of  chronic  renal  disease  or  diabetes  mellitus.The  previously  recognized  Kyrle  disease  (KD),  acquired  elastosis  perforans  serpiginosa  (AEPS),  acquired  perforating  collagenosis  (APC),  and  perforating  folliculitis  (PF)  are  now  classified  under  the  umbrella  term  of  acquired  perforating  dermatosis.Lesions  present  as  umbilicated  papules  and/or  nodules  with  a  central  keratotic  plug  or  crust  distributed  preferentially  on  extensor  surfaces  of  the  extremities.Histopathologic  examination  of  lesional  skin  demonstrates  invagination  of  the  epidermis  with  extrusion  of  dermal  material  (collagen,  elastin,  and/or  fibrin)  through  the  cup-shaped  epidermal  depression.Treatment  is  challenging  with  no  universally  effective  therapy,  and  patients  often  exhibit  a  chronic  course.