RT Book, Section A1 Nedorost, Susan T. A2 Kang, Sewon A2 Amagai, Masayuki A2 Bruckner, Anna L. A2 Enk, Alexander H. A2 Margolis, David J. A2 McMichael, Amy J. A2 Orringer, Jeffrey S. SR Print(0) ID 1161322666 T1 Irritant Dermatitis T2 Fitzpatrick's Dermatology, 9e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071837798 LK accessmedicine.mhmedical.com/content.aspx?aid=1161322666 RD 2024/10/04 AB AT-A-GLANCEIrritant dermatitis from wet-to-dry cycling is common in cold seasons.Decreasing the duration and frequency of contact with irritants may improve symptoms of irritant contact dermatitis (as opposed to allergic contact dermatitis which requires complete avoidance to clear).Innate immune signals from irritant dermatitis predispose to allergic dermatitis (allergic contact and atopic dermatitis).Emollients accelerate recovery and may help prevent the complication of allergic dermatitis in infants.Emollients used on normal skin over long intervals may predispose to irritant dermatitis.Hardening, or disappearance of symptoms, often occurs with continued irritant exposure without any treatment.Future understanding of ways to promote hardening could reduce the impact of allergic contact dermatitis and atopic disease which complicate irritant dermatitis.