RT Book, Section
A1 Simpson, Eric L.
A1 Leung, Donald Y. M.
A1 Eichenfield, Lawrence F.
A1 Boguniewicz, Mark
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161322297
T1 Atopic Dermatitis
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK accessmedicine.mhmedical.com/content.aspx?aid=1161322297
RD 2024/04/23
AB AT-A-GLANCEAtopic  dermatitis  (AD)  has  a  prevalence  peak  of  15%  to  20%  in  early  childhood  in  industrialized  countries.AD  has  variable  rates  of  remission,  with  many  patients  continuing  or  recurring  with  symptoms  into  adulthood.AD  is  a  chronic  or  chronically  relapsing  disorder  with  major  features  of:PruritusEczematous  dermatitis  (acute,  subacute,  or  chronic)  with  typical  morphology  and  age-specific  patternsFacial  and  extensor  involvement  in  infancyFlexural  eczema  or  lichenification  in  children  and  adultsCommonly  associated  with  the  following:Personal  or  family  history  of  atopy  (allergic  rhinitis,  asthma,  atopic  dermatitis)Xerosis  or  skin  barrier  dysfunctionImmunoglobulin  E  reactivityPathogenesis  driven  by  skin  barrier  defects  (most  importantly  in  the  FLG  gene),  environmental  effects  and  alterations  in  immunologic  responses  in  T  cells,  antigen  processing,  inflammatory  cytokines,  host  defense  proteins,  allergen  sensitivity,  and  infection.