RT Book, Section
A1 Tsai, Kenneth Y.
A1 Dlugosz, Andrzej A.
A2 Kang, Sewon
A2 Amagai, Masayuki
A2 Bruckner, Anna L.
A2 Enk, Alexander H.
A2 Margolis, David J.
A2 McMichael, Amy J.
A2 Orringer, Jeffrey S.
SR Print(0)
ID 1161321943
T1 Carcinogenesis and Skin
T2 Fitzpatrick's Dermatology, 9e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9780071837798
LK accessmedicine.mhmedical.com/content.aspx?aid=1161321943
RD 2024/04/24
AB AT-A-GLANCEThe  estimated  annual  incidence  of  skin  carcinomas  is  at  least  twofold  higher  than  that  of  all  other  cancers  combined,  making  these  cancers  a  major  burden  on  the  U.S.  health  care  system  and  a  source  of  significant  morbidity  and  mortality.Most  skin  cancers  arise  because  of  mutations  caused  by  ultraviolet  radiation  in  sunlight,  with  chemical  carcinogens,  oncogenic  viruses,  and  other  factors  contributing  to  the  development  of  a  smaller  proportion  of  tumors.The  convergence  of  evidence  from  epidemiology,  inherited  predisposition  syndromes,  cancer  genetics,  animal  models,  and  most  recently  genomics  have  collectively  revealed  unprecedented  insights  into  the  key  causative  events  that  drive  the  development  of  basal  cell  carcinoma  (BCC)  and  squamous  cell  carcinoma  (SCC).BCC  and  SCC  display  markedly  different  dependencies  on  specific  pathways:  whereas  BCC  is  almost  exclusively  a  Hedgehog  pathway—dependent  tumor,  SCC  appears  to  rely  on  a  more  varied  set  of  gene  mutations  and  oncogenic  signaling.The  accessibility  of  skin  and  the  ability  to  model  cancer  development  in  animals  has  been  highly  useful  in  identifying  the  components  and  functions  of  key  oncogenic  signaling  pathways,  facilitating  development  of  targeted  therapeutics,  and  uncovering  general  principles  of  cancer  biology.