RT Book, Section
A1 Saylor, Deanna
A1 Sacktor, Ned
A1 Rumbaugh, Jeffrey
A1 Sevigny, Jeffrey
A1 Estanislao, Lydia B.
A2 Brust, John C.M.
SR Print(0)
ID 1159972808
T1 HIV Neurology
T2 CURRENT Diagnosis & Treatment: Neurology, 3e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259835315
LK accessmedicine.mhmedical.com/content.aspx?aid=1159972808
RD 2024/04/18
AB HIV  is  a  retrovirus  belonging  to  the  subfamily  Lentivirus  (slow  virus),  so-called  because  of  the  long  latency  period  between  primary  infection  and  the  CD4+  T-cell  depletion  that  characterizes  AIDS.  During  this  latency  period,  the  immune  system  becomes  dysregulated  and  a  chronic  proinflammatory  state  develops,  manifesting  with  hypergammaglobulinemia  and  an  increased  secretion  of  several  cytokines.  Many  neurologic  complications,  particularly  those  occurring  before  the  onset  of  AIDS,  are  attributable  to  immune-mediated  processes.  Without  virologic  control,  eventually  all  components  of  the  immune  system  (particularly  the  cellular  response)  become  deficient,  enabling  opportunistic  infections  and  malignancies  to  develop.