RT Book, Section A1 Mayeaux, Jr., E.J. A1 Diaz, Lucia A2 Usatine, Richard P. A2 Smith, Mindy A. A2 Mayeaux, Jr., E.J. A2 Chumley, Heidi S. SR Print(0) ID 1164362038 T1 Erythema Nodosum T2 The Color Atlas and Synopsis of Family Medicine, 3e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259862045 LK accessmedicine.mhmedical.com/content.aspx?aid=1164362038 RD 2024/04/24 AB A young woman presented to the office with several days of overall malaise, fever, and sore throat. At the time of presentation she noted some painful bumps on her lower legs, and denied trauma (Figure 186-1). No history of recent cough or change in bowel habits has been reported. The patient had no chronic medical problems, took no medications, and had no known drug allergies. Her temperature was slightly elevated, but other vitals were normal. On examination, her oropharynx revealed tonsillar erythema and exudates. Bilateral lower extremities were spotted with slightly raised, tender, erythematous nodules that varied in size from 2 to 6 cm. Rapid strep test was positive, and she was diagnosed clinically with erythema nodosum (EN) secondary to group A β-hemolytic Streptococcus. She was treated with penicillin and nonsteroidal anti-inflammatory drugs (NSAIDs) and was advised temporary bed rest. She experienced complete resolution of the EN within 4 weeks.