RT Book, Section A1 van de Rijn, Marc A1 Tolchin, Dorothy Weiss A1 Paganoni, Sabrina A2 Mitra, Raj SR Print(0) ID 1159834997 T1 Myopathies T2 Principles of Rehabilitation Medicine YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071793339 LK accessmedicine.mhmedical.com/content.aspx?aid=1159834997 RD 2024/10/16 AB Myopathies are diseases characterized by primary muscle pathology.1 They can be inherited, acquired, associated with other diseases, or result from toxic exposures. The primary clinical manifestation of a myopathy is weakness, and accompanying symptoms can include (but are not limited to) wasting, cramps, spasms, myoclonus, contractures, and fatigue. Endurance and functional capacity are limited to varying degrees in different classes of myopathies. The pattern of weakness, constellation of associated symptoms, nature of progression, and other organ involvement together can point to a specific diagnosis (see Fig. 75–1).