RT Book, Section A1 Pasnoor, Mamatha A1 Dimachkie, Mazen M. A1 Farmakidis, Constantine A1 Barohn, Richard J. A2 Mitra, Raj SR Print(0) ID 1159834904 T1 Disorders of the Neuromuscular Junction: Myasthenia Gravis T2 Principles of Rehabilitation Medicine YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9780071793339 LK accessmedicine.mhmedical.com/content.aspx?aid=1159834904 RD 2024/10/05 AB Disorders affecting the neuromuscular junction (NMJ) are generally pure motor syndromes that usually affect the extraocular muscles but also the proximal limb and bulbar or respiratory function. They can be classified into autoimmune, acquired, toxic, and inherited disorders of the NMJ. The most common NMJ disorders are autoimmune and therefore respond to immunosuppressive therapy. These include myasthenia gravis (MG) and, rarely, the Lambert-Eaton myasthenic syndrome (LEMS). A number of genetically determined disorders of neuromuscular transmission, the congenital myasthenic syndromes, are seen in childhood but may rarely present in adult life. Botulism is a toxin-mediated disorder of the NMJ. All NMJ disorders cause generalized weakness and fatigability with a propensity for oculobulbar involvement. Electrophysiologic studies can detect an impairment of neuromuscular transmission in most of these disorders.1 Fortunately, most of these disorders are treatable2–4 (Fig. 74–1).