RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Trevor, Anthony J.
SR Print(0)
ID 1156531790
T1 Chemotherapeutic Drugs: Introduction
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 12e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259641022
LK accessmedicine.mhmedical.com/content.aspx?aid=1156531790
RD 2024/04/18
AB The  emergence  of  microbial  resistance  poses  a  constant  challenge  to  the  use  of  antimicrobial  drugs.  Mechanisms  underlying  microbial  resistance  include  the  production  of  antibiotic-inactivating  enzymes,  changes  in  the  structure  of  target  receptors,  increased  efflux  via  drug  transporters,  and  decreases  in  the  permeability  of  microbes’  cellular  membranes  to  antibiotics.  Strategies  designed  to  combat  microbial  resistance  include  the  use  of  adjunctive  agents  that  can  protect  against  antibiotic  inactivation,  the  use  of  antibiotic  combinations,  the  introduction  of  new  (and  often  expensive)  chemical  derivatives  of  established  antibiotics,  and  efforts  to  avoid  misuse  of  antibiotics.