RT Book, Section
A1 Katzung, Bertram G.
A1 Kruidering-Hall, Marieke
A1 Trevor, Anthony J.
SR Print(0)
ID 1156530510
T1 Antifungal Agents
T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 12e
YR 2019
FD 2019
PB McGraw-Hill Education
PP New York, NY
SN 9781259641022
LK accessmedicine.mhmedical.com/content.aspx?aid=1156530510
RD 2024/04/18
AB Fungal  infections  are  difficult  to  treat,  particularly  in  the  immunocompromised  or  neutropenic  patient.  Most  fungi  are  resistant  to  conventional  antimicrobial  agents,  and  relatively  few  drugs  are  available  for  the  treatment  of  systemic  fungal  diseases.  Amphotericin  B,  the  azoles  (fluconazole,  itraconazole,  ketoconazole,  and  voriconazole),  and  the  echinocandins  are  the  primary  drugs  used  in  systemic  infections.  They  are  selectively  toxic  to  fungi  because  they  interact  with  or  inhibit  the  synthesis  of  ergosterol,  a  sterol  unique  to  fungal  cell  membranes.