RT Book, Section A1 Katzung, Bertram G. A1 Kruidering-Hall, Marieke A1 Trevor, Anthony J. SR Print(0) ID 1156530032 T1 Pancreatic Hormones, Antidiabetic Drugs, & Glucagon T2 Katzung & Trevor's Pharmacology: Examination & Board Review, 12e YR 2019 FD 2019 PB McGraw-Hill Education PP New York, NY SN 9781259641022 LK accessmedicine.mhmedical.com/content.aspx?aid=1156530032 RD 2024/03/28 AB In the endocrine pancreas, the islets of Langerhans produce several types of hormones. The hormones include insulin, the anabolic hormone (B or beta cells); glucagon, the hyperglycemic factor (A or alpha cells); amylin, which modulates appetite (beta cells); somatostatin, the universal inhibitor of secretion (delta cells); and pancreatic polypeptide, facilitating digestion (F cells). Of these, the B (insulin-producing) cells are the most numerous.The most common pancreatic disease requiring pharmacologic therapy is diabetes mellitus, a deficiency of insulin production or effect. Diabetes is treated with several parenteral formulations of insulin and oral or parenteral noninsulin antidiabetic agents. Glucagon, a hormone that affects the liver, cardiovascular system, and gastrointestinal tract, can be used to treat severe hypoglycemia.