RT Book, Section
A1 Bringhurst, F. Richard
A1 Demay, Marie B.
A1 Kronenberg, Henry M.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1183992967
T1 Bone and Mineral Metabolism in Health and Disease
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1183992967
RD 2024/04/19
AB Bone  is  a  dynamic  tissue  that  is  remodeled  constantly  throughout  life.  The  arrangement  of  compact  and  cancellous  bone  provides  strength  and  density  suitable  for  both  mobility  and  protection.  Compact  or  cortical  bone  forms  the  roughly  cylindrical  shell  of  long  bones;  cancellous  or  trabecular  bone  forms  the  plate-like  meshwork  that  internally  supports  the  cortical  shell.  In  addition,  bone  provides  a  reservoir  for  calcium,  magnesium,  phosphorus,  sodium,  and  other  ions  necessary  for  homeostatic  functions.  Bone  also  hosts  and  regulates  hematopoiesis  by  providing  niches  for  hematopoietic  cell  proliferation  and  differentiation.  The  skeleton  is  highly  vascular  and  receives  about  10%  of  the  cardiac  output.  Remodeling  of  bone  is  accomplished  by  two  distinct  cell  types:  osteoblasts  produce  bone  matrix,  and  osteoclasts  resorb  the  matrix.  The  activities  of  these  cells  are  coordinated  by  osteocytes,  long-lived  regulatory  cells  embedded  within  bone  matrix.