RT Book, Section
A1 Rader, Daniel J.
A1 Kathiresan, Sekar
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1183992782
T1 Disorders of Lipoprotein Metabolism
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1183992782
RD 2024/04/25
AB Lipoproteins  are  complexes  of  lipids  and  proteins  that  are  essential  for  transport  of  cholesterol,  triglycerides  (TGs),  and  fat-soluble  vitamins  in  the  blood.  Disorders  of  lipoprotein  metabolism  include  primary  and  secondary  conditions  that  substantially  increase  or  decrease  specific  circulating  lipids  (e.g.,  cholesterol  or  TGs)  or  lipoproteins  (e.g.,  low  density  or  high  density  lipoproteins,  see  below).  The  demonstration  that  cholesterol-lowering  therapy  significantly  reduces  the  clinical  complications  of  atherosclerotic  cardiovascular  disease  (ASCVD)  makes  it  important  for  clinicians  to  be  familiar  with  the  diagnosis  and  treatment  of  lipoprotein  disorders.  This  chapter  reviews  normal  lipoprotein  physiology,  the  pathophysiology  of  disorders  of  lipoprotein  metabolism,  the  effects  of  genetic  and  environmental  factors  on  lipoprotein  metabolism,  and  the  clinical  approaches  to  the  diagnosis  and  management  of  lipoprotein  disorders.