RT Book, Section
A1 Flier, Jeffrey S.
A1 Maratos-Flier, Eleftheria
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1156520742
T1 Pathobiology of Obesity
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1156520742
RD 2024/04/18
AB In  a  world  where  food  supplies  are  intermittent,  the  ability  to  store  energy  in  excess  of  what  is  required  for  immediate  use  is  essential  for  survival.  Fat  cells,  residing  within  widely  distributed  adipose  tissue  depots,  are  adapted  to  store  excess  energy  efficiently  as  triglyceride  and,  when  needed,  to  release  stored  energy  as  free  fatty  acids  for  use  at  other  sites.  This  physiologic  system,  orchestrated  through  endocrine  and  neural  pathways,  permits  humans  to  survive  starvation  for  as  long  as  several  months.  However,  in  the  presence  of  nutritional  abundance  and  a  sedentary  lifestyle,  and  influenced  importantly  by  genetic  endowment,  this  system  increases  adipose  energy  stores  and  produces  adverse  health  consequences.