RT Book, Section
A1 Moutsopoulos, Haralampos M.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1156606666
T1 Sjögren’s Syndrome
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1156606666
RD 2024/04/25
AB Sjögren’s  syndrome  is  a  chronic,  slowly  progressing  autoimmune  disease  characterized  by  lymphocytic  infiltration  of  the  exocrine  glands  resulting  in  xerostomia  and  dry  eyes  (keratoconjunctivitis  sicca).  The  syndrome  has  unique  features  since  it  presents  with  a  wide  clinical  spectrum  from  organ-specific  autoimmune  exocrinopathy  to  systemic  disease.  A  small  but  significant  number  of  patients  develop  malignant  lymphoma.  The  disease  can  present  as  an  entity  alone  or  in  association  with  other  autoimmune  diseases  (Table  354-1).  Finally,  the  histopathologic  lesion  in  the  labial  minor  salivary  glands  is  easily  accessible  aiding  the  diagnosis,  prognosis  and  disease  pathogenesis.