RT Book, Section
A1 Goldhaber, Samuel Z.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1185558490
T1 Deep Venous Thrombosis and Pulmonary Thromboembolism
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1185558490
RD 2024/04/24
AB Venous  thromboembolism  (VTE)  encompasses  deep  venous  thrombosis  (DVT)  and  pulmonary  embolism  (PE)  and  causes  cardiovascular  death  and  disability  as  well  as  psychological  illness  and  emotional  distress.  In  the  United  States,  the  Surgeon  General  estimates  that  there  are  100,000  to  180,000  deaths  annually  from  PE  and  has  declared  that  PE  is  the  most  common  preventable  cause  of  death  among  hospitalized  patients.  In  a  Canadian  study,  almost  half  of  PE  patients  at  1  year  had  exercise  limitation,  decreased  walking  distance,  or  dyspnea,  which  lowered  their  quality  of  life.  Survivors  may  suffer  the  complications  of  chronic  thromboembolic  pulmonary  hypertension  or  postthrombotic  syndrome.  Chronic  thromboembolic  pulmonary  hypertension  causes  breathlessness,  especially  with  exertion.  Postthrombotic  syndrome  (also  known  as  chronic  venous  insufficiency)  damages  the  venous  valves  of  the  leg  and  worsens  the  quality  of  life  by  causing  ankle  or  calf  swelling  and  leg  aching,  especially  after  prolonged  standing.  In  its  most  severe  form,  postthrombotic  syndrome  causes  skin  ulceration  (Fig.  273-1).