RT Book, Section
A1 O’Gara, Patrick T.
A1 Loscalzo, Joseph
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1155974464
T1 Pulmonic Valve Disease
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1155974464
RD 2024/04/18
AB Pulmonic  valve  stenosis  (PS)  is  essentially  a  congenital  disorder  (Table  262-1).  With  isolated  PS,  the  valve  is  typically  domed.  Dysplastic  pulmonic  valves  are  seen  as  part  of  the  Noonan  syndrome  (Chap.  275),  which  maps  to  chromosome  12.  Mutations  in  the  PTPN1  gene  are  associated  with  about  half  of  all  cases  of  Noonan  syndrome.  Much  less  common  etiologies  include  carcinoid  and  obstructing  tumors  or  bulky  vegetations.  The  pulmonic  valve  is  only  very  rarely  affected  by  the  rheumatic  process.