RT Book, Section A1 John, Roy M. A1 Stevenson, William G. A2 Jameson, J. Larry A2 Fauci, Anthony S. A2 Kasper, Dennis L. A2 Hauser, Stephen L. A2 Longo, Dan L. A2 Loscalzo, Joseph SR Print(0) ID 1156562487 T1 Sustained Ventricular Tachycardia T2 Harrison's Principles of Internal Medicine, 20e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259644016 LK accessmedicine.mhmedical.com/content.aspx?aid=1156562487 RD 2024/03/29 AB Sustained monomorphic ventricular tachycardia (VT) presents as a wide QRS tachycardia that has the same QRS configuration from beat to beat indicating an identical sequence of ventricular depolarization for each beat (see Fig. 247-3A). VT originates from a stable focus or reentry circuit. In structural heart disease, the substrate is often an area of patchy replacement fibrosis due to infarction, inflammation or prior cardiac surgery that creates anatomical or functional reentry pathways (see Fig. 247-5). Less commonly, VT is related to reentry or automaticity in a diseased Purkinje system. Idiopathic VT occurs in the absence of structural heart disease and is due to a focal region of automaticity or reentry involving a portion of the Purkinje system.