RT Book, Section
A1 Kim, Kami
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1156506651
T1 Toxoplasma Infections
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1156506651
RD 2024/04/19
AB Toxoplasmosis  is  caused  by  infection  with  the  obligate  intracellular  parasite  Toxoplasma  gondii.  Acute  infection  acquired  after  birth  may  be  asymptomatic  but  is  thought  to  result  in  the  lifelong  chronic  persistence  of  cysts  in  the  host’s  tissues.  In  both  acute  and  chronic  toxoplasmosis,  the  parasite  is  responsible  for  clinically  evident  disease,  including  lymphadenopathy,  encephalitis,  myocarditis,  and  pneumonitis.  Congenital  toxoplasmosis  is  an  infection  of  newborns  that  results  from  the  transplacental  passage  of  parasites  from  an  infected  mother  to  the  fetus.  These  infants  may  be  asymptomatic  at  birth,  but  many  later  manifest  a  wide  range  of  signs  and  symptoms,  including  chorioretinitis,  strabismus,  epilepsy,  and  psychomotor  retardation.  In  immunocompetent  individuals,  toxoplasmosis  can  also  present  as  acute  disease  (typically  chorioretinitis)  associated  with  food-  or  waterborne  sources.