RT Book, Section
A1 Brown, Darron R.
A1 Ermel, Aaron
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1159154909
T1 Human Papillomavirus Infections
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1159154909
RD 2024/04/23
AB Interest  in  human  papillomavirus  (HPV)  infection  began  in  earnest  in  the  1980s  after  Harold  zur  Hausen  postulated  that  infection  with  these  viruses  was  associated  with  cervical  cancer.  It  is  now  recognized  that  HPV  infection  of  the  human  genital  tract  is  extremely  common  and  causes  clinical  conditions  ranging  from  asymptomatic  infection  to  genital  warts  (condylomata  acuminata);  dysplastic  lesions  and  invasive  cancers  of  the  anus,  penis,  vulva,  vagina,  and  cervix;  and  a  subset  of  oropharyngeal  cancers.  This  chapter  describes  the  epidemiology  of  HPV  as  a  virus  and  a  pathogen,  the  natural  history  of  HPV  infections  and  associated  cancers,  strategies  to  prevent  infection  and  HPV-associated  disease,  and  treatment  modalities  for  some  conditions  caused  by  HPV.