RT Book, Section
A1 Bryant, Amy E.
A1 Stevens, Dennis L.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1160013326
T1 Gas Gangrene and Other Clostridial Infections
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1160013326
RD 2024/04/20
AB The  genus  Clostridium  encompasses  >60  species  that  may  be  commensals  of  the  gut  microflora  or  may  cause  a  variety  of  infections  in  humans  and  animals  through  the  production  of  a  plethora  of  proteinaceous  exotoxins.  C.  tetani  and  C.  botulinum,  for  example,  cause  specific  clinical  disease  by  elaborating  single  but  highly  potent  toxins.  In  contrast,  C.  perfringens  and  C.  septicum  cause  aggressive  necrotizing  infections  that  are  attributable  to  multiple  toxins,  including  bacterial  proteases,  phospholipases,  and  cytotoxins.