RT Book, Section
A1 Blum, William
A1 Bloomfield, Clara D.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1160012675
T1 Acute Myeloid Leukemia
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1160012675
RD 2024/04/19
AB Acute  myeloid  leukemia  (AML)  is  a  neoplasm  characterized  by  infiltration  of  the  blood,  bone  marrow,  and  other  tissues  by  proliferative,  clonal,  poorly  differentiated  cells  of  the  hematopoietic  system.  These  leukemias  comprise  a  spectrum  of  malignancies  that,  untreated,  are  uniformly  fatal.  In  2016,  the  estimated  number  of  new  AML  cases  in  the  United  States  was  19,950,  comprising  ~1.2%  of  all  cancer  cases.  AML  is  the  most  common  acute  leukemia  in  older  patients,  with  a  median  age  at  diagnosis  of  67  years.  Long-term  survival  is  infrequent;  U.S.  registry  data  report  that  only  27%  of  patients  survive  5  years.