RT Book, Section
A1 Scadden, David T.
A1 Longo, Dan L.
A2 Jameson, J. Larry
A2 Fauci, Anthony S.
A2 Kasper, Dennis L.
A2 Hauser, Stephen L.
A2 Longo, Dan L.
A2 Loscalzo, Joseph
SR Print(0)
ID 1156505677
T1 Hematopoietic Stem Cells
T2 Harrison's Principles of Internal Medicine, 20e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259644016
LK accessmedicine.mhmedical.com/content.aspx?aid=1156505677
RD 2022/06/25
AB All  of  the  cell  types  in  the  peripheral  blood  and  some  cells  in  every  tissue  of  the  body  are  derived  from  hematopoietic  (hemo:  blood;  poiesis:  creation)  stem  cells.  If  the  hematopoietic  stem  cell  is  damaged  and  can  no  longer  function  (e.g.,  due  to  a  nuclear  accident),  a  person  would  survive  2–4  weeks  in  the  absence  of  extraordinary  support  measures.  With  the  clinical  use  of  hematopoietic  stem  cells,  tens  of  thousands  of  lives  are  saved  each  year  (Chap.  110).  Stem  cells  produce  hundreds  of  billions  of  blood  cells  daily  from  a  stem  cell  pool  that  is  estimated  to  be  only  in  the  tens  of  thousands.  How  stem  cells  do  this,  how  they  persist  for  many  decades  despite  the  production  demands,  and  how  they  may  be  better  used  in  clinical  care  are  important  issues  in  medicine.