RT Book, Section A1 Llovet, Josep M. A2 Jameson, J. Larry A2 Fauci, Anthony S. A2 Kasper, Dennis L. A2 Hauser, Stephen L. A2 Longo, Dan L. A2 Loscalzo, Joseph SR Print(0) ID 1156514128 T1 Tumors of the Liver and Biliary Tree T2 Harrison's Principles of Internal Medicine, 20e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259644016 LK accessmedicine.mhmedical.com/content.aspx?aid=1156514128 RD 2024/03/28 AB The burden of cancer is increasing worldwide. Lung, breast, and colorectal cancers are the most commonly diagnosed while lung and liver cancers are the most common causes of cancer death. Liver cancer is the sixth most common cancer worldwide, the second leading cause of cancer-related deaths and one of the few neoplasms whose incidence and mortality rates have been steadily increasing. Liver cancer comprises a heterogeneous group of malignant tumors with different histologic features and unfavorable prognosis that range from hepatocellular carcinoma (HCC; 85–90% cases), intrahepatic cholangiocarcinoma (iCCA; 10%), and other malignancies accounting for <1% of tumors, such as fibrolamellar HCC, mixed HCC-iCCA, epithelioid hemangiothelioma, and the pediatric cancer hepatoblastoma. The burden of liver cancer is increasing globally in almost all countries, and it is estimated to reach one million cases by 2030.