RT Book, Section A1 Mescher, Anthony L. SR Print(0) ID 1160662354 T1 Hemopoiesis T2 Junqueira’s Basic Histology: Text and Atlas, 15e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781260026177 LK accessmedicine.mhmedical.com/content.aspx?aid=1160662354 RD 2024/04/25 AB Mature blood cells have a relatively short life span and must be continuously replaced with new cells from precursors developing during hemopoiesis (Gr. haima, blood + poiesis, a making). In the early embryo these blood cells arise in the yolk sac mesoderm. In the second trimester, hemopoiesis (also called hematopoiesis) occurs primarily in the developing liver, with the spleen playing a minor role (Figure 13–1). Skeletal elements begin to ossify and bone marrow develops in their medullary cavities, so in the third-trimester marrow of specific bones becomes the major hemopoietic organ.