RT Book, Section
A1 Botham, Kathleen M.
A1 Mayes, Peter A.
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1160192486
T1 Oxidation of Fatty Acids: Ketogenesis
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accessmedicine.mhmedical.com/content.aspx?aid=1160192486
RD 2024/04/18
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Describe  the  processes  by  which  fatty  acids  are  transported  in  the  blood,  activated  and  transported  into  the  matrix  of  the  mitochondria  for  breakdown  to  obtain  energy.Outline  the  β-oxidation  pathway  by  which  fatty  acids  are  metabolized  to  acetyl-CoA  and  explain  how  this  leads  to  the  production  of  large  quantities  of  ATP.Identify  the  three  compounds  termed  “ketone  bodies”  and  describe  the  reactions  by  which  they  are  formed  in  liver  mitochondria.Recognize  that  ketone  bodies  are  important  fuels  for  extrahepatic  tissues  and  indicate  the  conditions  in  which  their  synthesis  and  use  are  favored.Indicate  the  three  stages  in  the  metabolism  of  fatty  acids  where  ketogenesis  is  regulated.Indicate  that  overproduction  of  ketone  bodies  leads  to  ketosis  and,  if  prolonged,  ketoacidosis,  and  identify  pathologic  conditions  when  this  occurs.Give  examples  of  diseases  associated  with  impaired  fatty  acid  oxidation.