RT Book, Section A1 Kennelly, Peter J. A1 Murray, Robert K. A2 Rodwell, Victor W. A2 Bender, David A. A2 Botham, Kathleen M. A2 Kennelly, Peter J. A2 Weil, P. Anthony SR Print(0) ID 1160193256 T1 Muscle & the Cytoskeleton T2 Harper's Illustrated Biochemistry, 31e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259837937 LK accessmedicine.mhmedical.com/content.aspx?aid=1160193256 RD 2024/03/28 AB OBJECTIVESAfter studying this chapter, you should be able to:Describe the differences between actin-based and myosin-based regulation of muscle contraction.Outline the composition and organization of the thick and thin filaments in striated muscle tissues.Describe the pivotal role of Ca2+ in the initiation of both contraction and relaxation in muscle.List the various channels, pumps, and exchangers involved in regulating intracellular Ca2+ levels in various types of muscle.List the major energy sources for regenerating ATP in muscle tissue.Identify the preferred energy sources for fast and slow twitch fibers.Understand the molecular bases of malignant hyperthermia, Duchenne and Becker muscular dystrophies, and inherited cardiomyopathies.Explain how nitric oxide (NO) induces relaxation of vascular smooth muscle.Know the general structures and functions of the major components of the cytoskeleton, namely microfilaments, microtubules, and intermediate filaments.Explain the role of mutations in the gene encoding lamin A and lamin in Hutchinson-Gilford progeria syndrome (progeria).