RT Book, Section
A1 Rodwell, Victor W.
A2 Rodwell, Victor W.
A2 Bender, David A.
A2 Botham, Kathleen M.
A2 Kennelly, Peter J.
A2 Weil, P. Anthony
SR Print(0)
ID 1162228963
T1 Conversion of Amino Acids to Specialized Products
T2 Harper's Illustrated Biochemistry, 31e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259837937
LK accessmedicine.mhmedical.com/content.aspx?aid=1162228963
RD 2024/04/19
AB OBJECTIVESAfter  studying  this  chapter,  you  should  be  able  to:Cite  examples  of  how  amino  acids  participate  in  a  variety  of  biosynthetic  processes  other  than  protein  synthesis.Outline  how  arginine  participates  in  the  biosynthesis  of  creatine,  nitric  oxide  (NO),  putrescine,  spermine,  and  spermidine.Indicate  the  contribution  of  cysteine  and  of  β-alanine  to  the  structure  of  coenzyme  A.Discuss  the  role  played  by  glycine  in  drug  catabolism  and  excretion.Document  the  role  of  glycine  in  the  biosynthesis  of  heme,  purines,  creatine,  and  sarcosine.Identify  the  reaction  that  converts  an  amino  acid  to  the  neurotransmitter  histamine.Document  the  role  of  S-adenosylmethionine  in  metabolism.Recognize  the  structures  of  tryptophan  metabolites  serotonin,  melatonin,  tryptamine,  and  indole  3-acetate.Describe  how  tyrosine  gives  rise  to  norepinephrine  and  epinephrine.Illustrate  the  key  roles  of  peptidyl  serine,  threonine,  and  tyrosine  in  metabolic  regulation  and  signal  transduction  pathways.Diagram  the  roles  of  glycine,  arginine,  and  S-adenosylmethionine  in  the  biosynthesis  of  creatine.Explain  the  role  of  creatine  phosphate  in  energy  homeostasis.Illustrate  the  formation  of  γ-aminobutyrate  (GABA)  and  the  rare  metabolic  disorders  associated  with  defects  in  GABA  catabolism.