RT Book, Section A1 Mathur, Piyush A1 Mehta, Ravindra L. A2 Lerma, Edgar V. A2 Rosner, Mitchell H. A2 Perazella, Mark A. SR Print(0) ID 1149116535 T1 Continuous Renal Replacement Therapy T2 CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259861055 LK accessmedicine.mhmedical.com/content.aspx?aid=1149116535 RD 2023/01/26 AB Renal replacement therapy (RRT) can be provided as hemodialysis, hemofiltration, or a combination thereof and as intermittent, or as continuous therapy. Continuous renal replacement therapy (CRRT) represents a number of technically distinct modalities characterized by slow per-minute solute clearance and ultrafiltration rates that are spread over most or all of the day to minimize wide metabolic or volume shifts. The longer duration of therapy has been associated with greater hemodynamic stability and a higher likelihood of kidney recovery compared to standard intermittent hemodialysis (IHD). CRRT encompass several methods of hemofiltration and hemodialysis and is being increasingly utilized for managing patients with AKI in the intensive care unit (ICU) setting. This chapter reviews the major terms used in the delivery of CRRT, the most prominent clinical and technical issues encountered by the healthcare teams, and promising technologies that may improve the efficacy and future applicability of the relevant modalities.