RT Book, Section A1 Rocco, Michael V. A1 Moossavi, Shahriar A2 Lerma, Edgar V. A2 Rosner, Mitchell H. A2 Perazella, Mark A. SR Print(0) ID 1149116333 T1 Hemodialysis T2 CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259861055 LK accessmedicine.mhmedical.com/content.aspx?aid=1149116333 RD 2024/04/19 AB The major forces responsible for solute transport across the membrane are diffusion and convection. Diffusion is influenced by the concentration gradient of the solute, the solute characteristics (eg, molecular weight and charge), and the membrane characteristics (eg, pore size and number). Removal of solutes by diffusion is enhanced by a large concentration gradient, small solute size, and a membrane with a large surface area and many large pores. The concentration gradient is maximized by using countercurrent flow of blood and dialysate.