RT Book, Section
A1 Leung, Nelson
A1 Nasr, Samih H.
A2 Lerma, Edgar V.
A2 Rosner, Mitchell H.
A2 Perazella, Mark A.
SR Print(0)
ID 1149114485
T1 Plasma Cell Dyscrasias
T2 CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259861055
LK accessmedicine.mhmedical.com/content.aspx?aid=1149114485
RD 2024/04/23
AB ESSENTIALS  OF  DIAGNOSISImmune  deposits  are  considered  monotypic  if  they  display  light  chain  restriction.Heavy  chain  restriction  without  light  chain  restriction  is  not  considered  monotypic  as  several  polyclonal  diseases  can  have  heavy  chain  isotype  restriction.C3  glomerulonephritis  and  thrombotic  microangiopathy  do  not  have  immunoglobulin  deposits  but  can  be  due  to  monoclonal  gammopathy.Immunofluorescence  (IF)  on  paraffin  tissue  after  protease  digestion  should  be  performed  on  all  cases  of  C3  glomerulonephritis  with  monoclonal  gammopathy  to  look  for  masked  immunoglobulin  deposits.All  amyloidosis  cases  should  undergo  tissue  typing  prior  to  initiation  of  chemotherapy.