RT Book, Section
A1 Madan, Niti
A1 Hwang, Vicki J.
A1 Yeun, Jane Y.
A1 Weiss, Robert H.
A2 Lerma, Edgar V.
A2 Rosner, Mitchell H.
A2 Perazella, Mark A.
SR Print(0)
ID 1149114016
T1 Immunoglobulin A Nephropathy and Henoch–Schönlein Purpura
T2 CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259861055
LK accessmedicine.mhmedical.com/content.aspx?aid=1149114016
RD 2024/09/17
AB ESSENTIALS  OF  DIAGNOSISIgA  nephropathy  is  the  most  common  form  of  glomerular  disease  in  the  world.IgA  nephropathy  is  characterized  by  frequent  bouts  of  microscopic  and/or  macroscopic  hematuria,  often  following  an  upper  respiratory  infection  (URI).The  pathophysiology  of  IgA  nephropathy  is  related  to  aberrant  glycosylation  of  the  IgA  molecule.The  pathogenesis  of  IgA  nephropathy  is  considered  to  involve  a  “multi-hit”  model.The  diagnosis  is  established  by  kidney  biopsy  showing  prominent  globular  deposits  of  IgA  often  accompanied  by  C3  and  IgG  in  the  mesangium.There  is  no  specific  treatment  of  IgA  nephropathy  and  10–20%  of  patients  with  the  disease  will  progress  to  end-stage  kidney  disease  within  10  years  of  diagnosis,  and  25–40%  within  20  years.