RT Book, Section
A1 Alfaadhel, Talal A.
A1 Fervenza, Fernando C.
A1 Cattran, Daniel C.
A2 Lerma, Edgar V.
A2 Rosner, Mitchell H.
A2 Perazella, Mark A.
SR Print(0)
ID 1149113920
T1 Membranous Nephropathy
T2 CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259861055
LK accessmedicine.mhmedical.com/content.aspx?aid=1149113920
RD 2024/04/19
AB ESSENTIALS  OF  DIAGNOSISNephrotic  syndrome  is  the  typical  presenting  feature.The  glomerular  basement  membranes  (GBMs)  appear  thickened  on  light  microscopy.There  is  an  absence  of  glomerular  inflammation.Primary  (PLA2R  or  THSD7A  antigen  related)  membranous  nephropathy  (MN)  is  a  leading  cause  of  nephrotic  syndrome  in  adults.Secondary  MN  forms  can  account  for  up  to  one-third  of  cases.Malignancy  as  a  secondary  cause  increases  with  age.Conservative  management  should  be  the  first  step  in  management.Risk  of  progression  of  the  disease  needs  to  be  considered  because  patients  with  a  high  risk  of  progression  can  benefit  from  immunosuppressive  treatment.