RT Book, Section A1 Trachtman, Howard A1 Gipson, Debbie S. A2 Lerma, Edgar V. A2 Rosner, Mitchell H. A2 Perazella, Mark A. SR Print(0) ID 1149113826 T1 Focal Segmental Glomerulosclerosis T2 CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259861055 LK accessmedicine.mhmedical.com/content.aspx?aid=1149113826 RD 2024/03/28 AB ESSENTIALS OF DIAGNOSISFocal segmental glomerulosclerosis (FSGS) can be primary or secondary.Diagnosis requires the presence of the characteristic histopathologic lesion.Genetic abnormalities in podocyte proteins may account for 25% of primary FSGS in high-risk populations.The presenting complaint is usually proteinuria or nephrotic syndrome.Nearly 50% of cases progress to end-stage renal disease (ESRD) over 5–10 years and disease recurs in up to 20% of those who receive a kidney transplant.Failure to respond to corticosteroid treatment is a poor prognostic sign and there is no proven therapy in these patients.