RT Book, Section
A1 Rastegar, Mandana
A1 Shirali, Anushree
A2 Lerma, Edgar V.
A2 Rosner, Mitchell H.
A2 Perazella, Mark A.
SR Print(0)
ID 1149112562
T1 Tumor Lysis Syndrome
T2 CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259861055
LK accessmedicine.mhmedical.com/content.aspx?aid=1149112562
RD 2024/04/23
AB Essentials  of  DiagnosisDue  to  tumor  cell  lysis  (TLS),  commonly  in  high-risk  hematologic  malignancies  and/or  tumors  with  large  cellular  burden.Results  when  intracellular  contents  of  nucleic  acids,  potassium,  phosphorus  are  rapidly  released  into  the  bloodstream.Characterized  by  laboratory  findings  of  hyperuricemia,  hyperkalemia,  hyperphosphatemia,  and/or  hypocalcemia  with  clinical  manifestations  of  renal,  cardiac,  and/or  neurologic  dysfunction.Knowledge  of  risk  factors  of  TLS  and  early  detection  of  TLS  are  imperative  to  implementing  preventive  and  therapeutic  strategies  to  reduce  morbidity  and  mortality.