RT Book, Section
A1 Katzung, Bertram G.
SR Print(0)
ID 1148443550
T1 Chemotherapeutic Drugs: Introduction
T2 Basic & Clinical Pharmacology, 14e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259641152
LK accessmedicine.mhmedical.com/content.aspx?aid=1148443550
RD 2024/04/16
AB Antimicrobial  agents  provide  some  of  the  most  dramatic  examples  of  the  advances  of  modern  medicine.  Many  infectious  diseases  once  considered  incurable  and  potentially  lethal  can  now  be  treated  effectively  with  antibiotics.  The  remarkably  powerful  and  specific  activity  of  antimicrobial  drugs  is  due  to  their  selectivity  for  targets  that  are  either  unique  to  prokaryote  and  fungal  microorganisms  or  much  more  important  in  these  organisms  than  in  humans.  Among  these  targets  are  bacterial  and  fungal  cell  wall-synthesizing  enzymes  (Chapters  43  and  48),  the  bacterial  ribosome  (Chapters  44  and  45),  the  enzymes  required  for  nucleotide  synthesis  and  DNA  replication  (Chapter  46),  and  the  machinery  of  viral  replication  (Chapter  49).  The  special  group  of  drugs  used  in  mycobacterial  infections  is  discussed  in  Chapter  47.  Cytotoxic  antiseptics  and  disinfectants  are  discussed  in  Chapter  50.  The  clinical  uses  of  many  antimicrobial  agents  are  summarized  in  Chapter  51.