RT Book, Section A1 Horn, John R. A2 Katzung, Bertram G. SR Print(0) ID 1148443542 T1 Important Drug Interactions & Their Mechanisms T2 Basic & Clinical Pharmacology, 14e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259641152 LK accessmedicine.mhmedical.com/content.aspx?aid=1148443542 RD 2024/04/16 AB One of the factors that can alter the response to drugs is the concurrent administration of other drugs. There are several mechanisms by which drugs may interact, but most can be categorized as pharmacokinetic (absorption, distribution, metabolism, excretion), pharmacodynamic (additive, synergistic, or antagonistic effects), or combined interactions. The general principles of pharmacokinetics are discussed in Chapters 3 and 4; the general principles of pharmacodynamics are discussed in Chapter 2.