RT Book, Section
A1 Chrousos, George P.
A2 Katzung, Bertram G.
SR Print(0)
ID 1148439387
T1 The Gonadal Hormones & Inhibitors
T2 Basic & Clinical Pharmacology, 14e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259641152
LK accessmedicine.mhmedical.com/content.aspx?aid=1148439387
RD 2024/04/24
AB CASE  STUDYA  25-year-old  woman  with  menarche  at  13  years  and  menstrual  periods  until  about  1  year  ago  complains  of  hot  flushes,  skin  and  vaginal  dryness,  weakness,  poor  sleep,  and  scanty  and  infrequent  menstrual  periods  of  a  year’s  duration.  She  visits  her  gynecologist,  who  obtains  plasma  levels  of  follicle-stimulating  hormone  and  luteinizing  hormone,  both  of  which  are  moderately  elevated.  She  is  diagnosed  with  premature  ovarian  failure,  and  estrogen  and  progesterone  replacement  therapy  is  recommended.  A  dual-energy  absorptiometry  scan  (DEXA)  reveals  a  bone  density  t-score  of  <2.5  SD,  ie,  frank  osteoporosis.  How  should  the  ovarian  hormones  she  lacks  be  replaced?  What  extra  measures  should  she  take  for  her  osteoporosis  while  receiving  treatment?