RT Book, Section
A1 Schaefer, G. Bradley
A1 Thompson, Jr., James N.
SR Print(0)
ID 1147722698
T1 Mutation
T2 Medical Genetics: An Integrated Approach
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071664387
LK accessmedicine.mhmedical.com/content.aspx?aid=1147722698
RD 2024/04/23
AB In  earlier  chapters,  we  saw  how  genes  produce  the  enzymes  that  control  specific  biochemical  reactions.  Normal  development  depends  on  these  information  coding  and  regulatory  systems  working  properly.  But  DNA  replication  is  not  perfect.  Biochemical  mistakes  happen.  Most  replication  errors  are  corrected  by  repair  enzymes,  but  those  that  are  missed  become  new  mutations.  In  the  broadest  sense,  then,  a  mutation  is  a  heritable  genetic  change  passed  from  one  cell  to  another.  For  that  reason,  the  biochemical  correction  mechanisms  that  work  in  parallel  with  replication  are  important  for  biological  continuity.