RT Book, Section A1 Gumbo, Tawanda A2 Brunton, Laurence L. A2 Hilal-Dandan, Randa A2 Knollmann, Björn C. SR Print(0) ID 1162545357 T1 Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259584732 LK accessmedicine.mhmedical.com/content.aspx?aid=1162545357 RD 2024/03/29 AB Mycobacteria have caused epic diseases: TB and leprosy have terrorized humankind since antiquity. Although the burden of leprosy has decreased, TB is still the most important infectious killer of humans. Mycobacterium abscessus has now been called a new “antibiotic” nightmare because of its tenacity, lack of response to combination antibiotics, and a nearly universal propensity to develop acquired drug resistance. Mycobacterium avium-intracellulare (or MAC) infection continues to be difficult to treat, mainly due to three natural barriers: