RT Book, Section
A1 Roden, Dan M.
A2 Brunton, Laurence L.
A2 Hilal-Dandan, Randa
A2 Knollmann, Björn C.
SR Print(0)
ID 1162533468
T1 Pharmacogenetics
T2 Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259584732
LK accessmedicine.mhmedical.com/content.aspx?aid=1162533468
RD 2024/04/18
AB It  is  a  given  that  patients  vary  in  their  responses  to  drug  therapy.  Some  patients  derive  striking  and  sustained  benefits  from  drug  administration;  others  may  display  no  benefit,  and  still  others  display  mild,  severe,  or  even  fatal  adverse  drug  reactions  (ADRs).  Common  sources  of  such  variability  include  noncompliance,  medication  errors,  drug  interactions  (see  Chapter  4  and  Appendix  I),  and  genetic  factors.  Pharmacogenetics  is  the  study  of  the  genetic  basis  for  variation  in  drug  response  and  often  implies  large  effects  of  a  small  number  of  DNA  variants.  Pharmacogenomics,  on  the  other  hand,  studies  larger  numbers  of  variants,  in  an  individual  or  across  a  population,  to  explain  the  genetic  component  of  variable  drug  responses.  Discovering  which  variants  or  combinations  of  variants  have  functional  consequences  for  drug  effects,  validating  those  discoveries,  and  ultimately  applying  them  to  patient  care  and  to  drug  discovery  are  the  tasks  of  modern  pharmacogenetics  and  pharmacogenomics.