RT Book, Section A1 Stringer, Janet L. SR Print(0) ID 1142821178 T1 Drugs Used in Mood Disorders T2 Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 5e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259861079 LK accessmedicine.mhmedical.com/content.aspx?aid=1142821178 RD 2024/03/28 AB All of the antidepressant drugs increase the concentration of norepinephrine or serotonin in the synaptic cleft. In most cases, they do this by inhibiting the reuptake of the neurotransmitters. Remember that reuptake is the major route for termination of action of these neurotransmitters. Other drugs block their metabolic degradation or increase their release.