RT Book, Section A1 Varga, John A2 Jameson, J. Larry A2 Fauci, Anthony S. A2 Kasper, Dennis L. A2 Hauser, Stephen L. A2 Longo, Dan L. A2 Loscalzo, Joseph SR Print(0) ID 1179365261 T1 Systemic Sclerosis (Scleroderma) and Related Disorders T2 Harrison's Principles of Internal Medicine, 20e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259644016 LK accessmedicine.mhmedical.com/content.aspx?aid=1179365261 RD 2024/03/28 AB Systemic sclerosis (SSc) is a complex and clinically heterogeneous orphan disease with protean clinical manifestations, a chronic and frequently progressive course, and significant disability, disfigurement and mortality. Virtually every organ can be affected (Fig. 353-1).