RT Book, Section A1 Margolias, Gary A1 Sterling, Michael A2 McKean, Sylvia C. A2 Ross, John J. A2 Dressler, Daniel D. A2 Scheurer, Danielle B. SR Print(0) ID 1137614471 T1 Pain, Agitation, and Delirium in the Critical Care Setting T2 Principles and Practice of Hospital Medicine, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071843133 LK accessmedicine.mhmedical.com/content.aspx?aid=1137614471 RD 2024/04/19 AB Key Clinical Questions What are the clinical and pharmacologic effects of single agent versus multiple agent sedative and analgesic administration? What is the best way to dose sedative, analgesic, and paralytic agents in the intensive care unit (ICU)? How do the pharmacokinetics and dosing of sedative, analgesic, and paralytic agents change with duration of infusion? What is the proper sequence to initiate sedatives, analgesics, and/or paralytics, and how does dosing refinement affect time to weaning and other predictors of favorable outcome? How do you select individual sedative, analgesic, or paralytic agents in critically ill patients? When do you decide to paralyze a ventilated patient?